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reference: Wu G, Fang YZ, Yang S, Lupton JR, Turner ND

Long-term inflammation is linked to arthritis, asthma, and heart disease

Type I collagen is synthesized and secreted by fibroblasts, using the exocytic pathway that is employed for other secretory proteins (see Chapter 21), but the biosynthesis of collagen is noteworthy for the extensive number of processing steps required to prepare the protein for assembly in the extracellular matrix